nayana-c1.867c992ae9100904cc61c84591adf0f8f863e0387e30f0d0dbc86640e9f50a1a.en.train.180778

The task

Which of the following studies focused on the pharmacokinetics and metabolism of paclitaxel? A. Barthier S, Dieras V, Kalla S et al. A Phase I and pharmacokinetic (PK) study of RPR 109881A given as a 6-hour IV infusion in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol 1998; (Abstr 747). B. Huizing MT, Keung ACF, Rosing H et al. Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients. J Clin Oncol 1993; 11: 2127-2135. C. Gelmon KA, Latreille J, Tolcher A et al. Phase I dose finding study of a new taxane, RPR 109881A, administered as a 1-hour intravenous infusion days | and 8 to patients with advanced solid tumors. J Clin Oncol 2000; 18: 4098-4108. D. Rosing H, Lustig V, van Warmerdam LJC et al. Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion. Cancer Chemother Pharmacol 2000; 45: 213-218. Return only the single uppercase letter of the correct option.